Demixed principal component analysis of neural population data

Abstract

Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we demonstrate the advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a single figure.DOI: http://dx.doi.org/10.7554/eLife.10989.001

Wieland Brendel

Principal Investigator (PI)

Wieland Brendel received his Diploma in physics from the University of Regensburg (2010) and his Ph.D. in computational neuroscience from the École normale supérieure in Paris (2014). He joined the University of Tübingen as a postdoctoral researcher in the group of Matthias Bethge, became a Principal Investigator and Team Lead in the Tübingen AI Center (2018) and an Emmy Noether Group Leader for Robust Machine Learning (2020). In May 2022, Wieland joined the Max-Planck Institute for Intelligent Systems as an independent Group Leader and is now a Hector-endowed Fellow at the ELLIS Institute Tübingen (since September 2023). He received the 2023 German Pattern Recognition Award for his substantial contributions on robust, generalisable and interpretable machine vision. Aside of his research, Wieland co-founded a nationwide school competition (bw-ki.de) and a machine learning startup focused on visual quality control.